Program

SCHEDULE CHANGE: Kari Stefansson is unable to attend! See changes to Sunday Schedule

Click here to download the program for the CTC meeting. 

The CTC2010 meeting will last three and a half days, beginning on Friday, May 7 with a half day pre-meeting about the collaborative cross. We will have a 1 hour cocktail reception Friday night at Omni Hotel. The following three days will have a mixture of 60 minute keynote addresses from invited speakers, side talks drawn from submitted abstracts and organized loosely into sessions, and 2 poster sessions. Two evening computer/software demos will be held in the Omni Hotel. On Monday the closing banquet will be a dinner cruise aboard a ship on Lake Michigan. The schedule below is still under development. If you would like to help to organize the scientific program please use the "contact" link in the upper right.

Friday – May 7, Picasso Ballroom Omni Hotel (676 North Michigan Avenue)

2:00-7:00                     Registration open

3:00-6:00                     Current Status of the collaborative cross; Chair: Fernando Pardo-Manuel de Villena

Short Reports:  Reference Populations and Tools 

3:00            Gary Churchill (JAX).  Mouse Diversity array

3:10            Rob Williams (UT).  The BXD panel

3:20            Karen Svenson (JAX).  The Diversity Outcross

3:30            Michael Nachman (Univ of Arizona).  A Proposal for a Mouse panel derived from wild caught mice

Status and access to the CC

3:45            Darla Miller (UNC).  The CC (US population)

3:55            Fuad Iraqi (TAU).  The CC (Israel/Wellcome Trust population)

4:05            Grant Morahan (UWA).  The CC (Australia population)

4:15            Richard Mott (Oxford).  Pipeline and databases

4:25            Leonard McMillan (UNC).  Databases

4:35            Howard Dene (JAX).  Nomenclature. 

4:40            Terry Magnuson (UNC).  Rederivation, cryopreservation and genetic integrity

4:45            David Threadgill (NCSU) and Richard Mott (Oxford).  MTA and Access to the CC lines

5:00  Open Discussion

6:00-7:00                     Reception outside of Picasso Ballroom (Omni Hotel)

Saturday – May 8, Feinberg Pavilion (251 E. Huron St.)

8:00-6:30                     Registration open

8:00-9:00                     Breakfast/refreshments

9:00-10:00                   Speaker:  Nancy Cox "Forget the Missing Heritability — Worry about the Missing Biology."

10:00-10:15              Break/Refreshments

10:15-12:00                 Session 1 "Evolutionary Genetics of Wild House Mice" (session co-chairs: Betttina Harr and Bret Payseur)

10:15-10:30                 Michael Nachman (University of Arizona) "Genetic Variation in Wild Mice"

10:30-10:45                 Fernado Pardo-Manuel de Villena (University of North Carolina Chapel Hill) "Genome-wide maps of subspecific origin and identity by descent in the laboratory mouse"

 10:45-11:00                 Priscilla Tucker (University of Michigan) "Genome-wide dynamics in naturally occurring hybrid populations of Mus musculus domesticus and M. m. musculus."

11:00-11:15                 Leslie Turner (Max Planck Institute for Evolutionary Biology) "Male sterility in a natural house mouse hybrid zone."

11:15-11:30                 Jeffrey M. Good (University of Montana) "Widespread over-expression of the X chromosome in sterile F1 hybrid mice."

11:30-11:45                 Michael A. White (University of Wisconsin) "The genetics of hybrid male sterility between two subspecies of house mice, Mus musculus castaneus and M. m. domesticus."

11:45-12:00                 Bret Payseur (University of Wisconsin) "Evolution of the Meiotic Recombination Rate across the House Mouse Genome"

12:00-1:00                 Lunch

1:00-2:30                     Session 2 "The Power of Genetic Reference Populations" (session co-chairs: Rob Williams and Klaus Schughart)

1:00-1:15                     Justin Borevitz (University of Chicago) "Finescale Genetic Architecture of Seasonal Flowering Time Adaptation in Arabidopsis thaliana"

1:15-1:30                     Grant Morahan (University of Western Australia) "Gene Interactions In Type 1 Diabetes: A Systems Genetics Approach."

1:30-1:45                     James J. Crowley (University of North Carolina) "Genome-Wide Association Mapping of Susceptibility Genes for Antipsychotic-Induced Tardive-Dyskinesia in Mice."

1:45-2:00                     Shirng-Wern Tsaih (The Jackson Laboratory) "Mixed Model Analysis and Permutation for Recombinant Inbred Strain Panels."

2:00-2:15                     Xusheng Wang (University of Tennessee Health Science Center) "Whole-genome sequence of DBA/2J and its use for reverse complex trait analysis."

2:15-2:30                     Klaus Schughart (University of Vetrinary Medicine Hannover, Braunschweig, Germany) "Host susceptibility to influenza A infections."

2:30-3:00                     Come See My Poster (Poster Tsar: Robert Blank)

3:00-4:30                     Poster Session 1

4:30-5:30                     Speaker:  Trudy Mackay "Systems Genetics of Complex Traits in Drosophila."

5:30-6:30                   Reception with drinks and refreshments

6:30-8:00                     Free

8:00-9:30                     Three Computer Demos (Omni Hotel, Monet Room)

8-8:30:                          Andrew D. Skol: R/QTLRel: software for QTL analysis in AIL and other outbred populations

8:30-9:                          Keith Sheppard: J/maanova: Graphical user interface for the analysis of microarray experiments

9-9:30:                          Ricardo Verdugo: HTDAS: build and execute self-documenting workflows of data analysis

Sunday – May 9, Feinberg Pavilion (251 E. Huron St.)

8:00-5:30                     Registration open

8:00-9:00                     Breakfast/refreshments

9:00-10:00                   Speaker:  Jonathan Flint "How to find quantitative trait genes in the mouse"

10:00-10:30               Break/Refreshments

10:30-12:15                 Session 3 "Gene mapping in outbred animals" (session co-chairs: Leah Solberg-Woods and James Cheverud)

10:30-10:45                 Abraham A. Palmer (University of Chicago) "Fine mapping of QTLs using an advanced intercross line."

10:45-11:00                 Greta Sokoloff (University of Chicago) "Mapping quantitative trait loci contributing to anxiety-like behavior in an advanced intercross line and pre-CC mice"

11:00-11:15                 LC Solberg Woods (Medical College of Wisconsin) "Fine-mapping diabetic loci using heterogeneous stock rats."

11:015-11:30                 Jon Krohn (Wellcome Trust Centre for Human Genetics, University of Oxford)  "Gene-by-Environment Interactions Underlying Anxiety Investigated Across Six Murine Experiments."

11:30-11:45                 Jérôme Nicod (Wellcome Trust Centre for Human Genetics, University of Oxford) "Commercially available outbred mice for genome-wide association studies."

11:45-12:00                 Emily Cozzi (Division of Genetics, Brigham and Women’s Hospital) "Loci on chromosome 2 are associated with naïve airway hyperresponsiveness in CD-1 outbred mice."

12:00-12:15                 Weidong Zhang (The Jackson Laboratory) "Genome Wide Association of Quantitative Traits in Outbred Mice."

12:15-1:45                 Lunch

1:45-3:15                     Session 4 "Modifiers and Epigenetics" (session co-chairs: Kazuhiro Shimomura and Leo Schalkwyk)

1:45-2:00                     Kazuhiro Shimomura (Northwestern University) "Upstream Transcription Factor 1 (Usf1) is responsible for Suppressor of Clock (Soc): Uncovering a hidden transcription pathway for circadian clock genes."

2:00-2:15                     Ahlke Heydemann (University of Chicago) "Identification of genetic modifiers of single gene disorders."

2:15-2:30                     Alexander Platt (University of Southern California, Los Angeles) "Conditions under which Genome Wide Association studies will be positively misleading."

2:30-2:45                     LC Schalkwyk (King's College London) "Allelic skewing of DNA methylation is widespread across the genome."

2:45-3:00                     Kari A. Haus (University of California-Davis) "From a QTL to candidate genes: Identification of maternal effects loci using congenic mouse strains."

3:00-3:15                     Karen N. Conneely (Emory University) "Global and Gene-Specific Patterns of DNA Methylation Associated with Aging."

3:15-3:45                     Come See My Poster (Poster Tsar: Robert Blank)

3:45-5:30                     Poster Session 2

8:00-9:30                     Computer Demo: Karl Broman: R/qtl: software for QTL analysis (Omni Hotel, Monet Room) [Details here]

Monday – May 10, Feinberg Pavilion (251 E. Huron St.)

8:00-9:00                     Breakfast/refreshments

9:00-10:00                   Speaker:  Jonathan Pritchard "Unraveling the functional basis of human expression QTLs."

10:00-10:15               Break/Refreshments

10:15-12:00                 Session 5 "Statistical and Computational Methods" (session co-chairs: Gary Churchill and Karl Broman)

10:15-10:30                 Karl W. Broman (University of Wisconsin) "Mapping QTL to a phylogenetic tree."

10:30-10:45                 Richard Mott (Wellcome Trust Centre for Human Genetics) "Mapping Global Recombination Rates in Collaborative Cross Populations."

10:45-11:00                 Wei Wang (University of North Carolina at Chapel Hill) "HTreeQA: Using Semi-perfect Phylogeny Trees in Genome-wide Association Study on Genotype Data"

11:00-11:15                 John P. Didion (UNC Chapel Hill) "Increasing Mapping Power by Recovery of Genotyping Errors as Minimally Biased Markers."

11:15-11:30                 Sulin Wu (University of California Los Angeles) "PhenoNet – regulatory network for metabolic syndrome in mouse."

11:30-11:45                 Gregory W. Carter (University of North Carolina) "Analyzing Genetic Complexity with Genetic Interaction Networks."

11:45-12:00                 Gary Churchill (The Jackson Laboratory) "The Trouble Triples: Can we infer causality from ‘Omics’ data?"

12:00-1:00                 Lunch

1:00-2:30                     Session 6 "QTL, GWAS and Related Issues" (Session co-chairs: Robert Hitzemann and Vivek Kumar)

1:00-1:15                     Eva Redei (Northwestern University) "QTL for passive coping on chromosome X confirmed by congenic rat strain."

1:15-1:30                     Kent Hunter (NCI,NIH) "The metastasis susceptibility gene SIPA1 is a multifunctional molecule with multiple sub-cellular and sub-nuclear localizations."

1:30-1:45                     John M. Stylianou (University of Pennsylvania) "The next step from GWAS and eQTL candidate gene discovery: An in vivo follow up of novel genes identified through the Global Lipids Genetics Consortium."

1:45-2:00                     Peter T Vedell (Jackson Lab) "Transcript variation in C57BL/6J mice under normal laboratory conditions."

2:00-2:15                     Martin Goodson (Wellcome Trust Centre for Human Genetics) "Genes at Quantitative Trait Loci in the Mouse."

2:15-2:30                     Robert Hitzemann (Oregon Health & Science University) "Gene Networks and Catalepsy in Heterogeneous Stock (HS) Mice."

2:30-3:00                   Break/Refreshments

3:00-5:00                     Session 7 "Genetic Studies in the Emerging Collaborative Cross" (session co-chairs: William Valdar and Elissa Chesler)

3:00-3:15                      David L. Aylor (University of North Carolina) "Genetic Analysis of Complex Traits in the Emerging Collaborative Cross."

3:15-3:30                      Samir N. P. Kelada (National Human Genome Research Institute, NIH) "Identification Of Genetic Loci In Mice That Mediate Allergen-Induced Airway Hyper-Responsiveness, Inflammation, And Serum Igg1."

3:30-3:45                      Martin T. Ferris (UNC-Chapel Hill) "New insights into influenza pathogenesis using the Collaborative Cross."

3:45-4:00                      Lisa E. Gralinski (Univ. of North Carolina) "Genome wide identification of susceptibility loci to SARS Coronavirus using the Collaborative Cross."

4:00-4:15                      Caroline Durrant (University of Oxford) "Determining the Strains Driving QTL for Factors Controlling Anaemia Development in the PreCC."

4:15-4:30                      Fuad A. Iraqi (Tel Aviv University) "Mapping QTL associated with host susceptibility to Aspergillus fumigatus infection in the Collaborative Cross mouse resource population."

4:30-4:45                      Martin Striz (University of Kentucky) "Identification of sex-specific QTLs affecting sleep in BXD lines, and similar QTLs in the collaborative cross mice, using a novel piezoelectric system to monitor sleep."

4:45-5:00                      Catherine E. Welsh (University of North Carolina) "Techniques for Accelerating Inbreeding in the Collaborative Cross."

6:30-9:30                     Dinner Cruise, Depart from Navy Pier (ship leaves at 6:30, arrive early or you will miss the boat!)